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EXUS as Partner

A Cost-Effective Photonics-based Device for Early Prediction, Monitoring and Management of Diabetic Foot Ulcers

Early prediction and management of Diabetic Foot Ulcers (DFUs) is an important health factor of Europe. Recent clinical trials have concluded that NIR sensing captures oxy(deoxy)haemoglobin (HbO2, Hb) and peripheral/ tissue oxygen saturations (StO2, SpO2), thermal Infrared-IR detects hyperthermia, among Regions of Interest (ROIs) and Mid-IR contains rich information about the proteomics, lipidomics and metabolomics (e.g., glucose).

All these medical indices are important factors for early prediction of DFU. Current medical approaches are i) invasive (e.g., skin lesion biopsy), ii) requires consumables, and iii) being operated by certified physicians (e.g., ultrasound and/or biopsy). PHOOTONICS aims at developing a non-invasive, reliable and cost-effective photonics-driven device for DFU monitoring and management which can be applied for wide use. The project supports two versions: (i) the PHOOTONICS In-Home, used for DFU monitoring by patients and (ii) the PHOOTONICS PRO operated by physicians.

Reliability is achieved by optimizing i) passive Hyperspectral (HIS) NIR photo-detector, with an active tuneable diode illuminator for detecting SpO2/StO2, HbO2 and Hb, ii) a thermal-IR sensor of detecting hyperthermia/hypothermia distributions in ROIs and iii) a passive Mid-IR sensing with a Quantum Cascade Laser (QCL) optimized to capture additional tissue attributes such as proteomics (elastin, collagen) and metabolomics (glucose). Cost-effectiveness is achieved by introducing i) targeted photonics technologies for DFU, ii) implementing advanced signal processing/learning algorithms to increase the discrimination accuracy while maintaining hardware cost-benefit, (iii) developing a user-friendly framework operated by non-certified physicians, and even by patients (for the In-Home version), and (iv) minimising operational cost with our non-invasive device. Clinical studies are performed to validate the reliability of the new cost-effective device in real-life settings.

 

11/2019 - 04/2023

Project duration

4.624.784,25€

Overall Budget

ICT-05-2019

Topic

Impact

The expected impact of the PHOOTONICS project is summarized in the points below:
• PHOOTONICS a cost-effective device compared to traditional medical imaging and practices; it allows for a regular non-invasive monitoring of DFUs without any additional cost of consumables
• PHOOTONICS is a reliable and non-invasive DFU management medical device: It measures several medical indices important for DFU management and monitoring
• PHOOTONICS brings together several bio-photonics related market to deliver a portable, ease of use, non-invasive device for regular DFU monitoring

UAB METIS BALTIC

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM (Belgium)

ALPES LASERS SA (Switzerland)

QUEST PHOTONIC DEVICES BV

Partners

EXUS SOFTWARE MONOPROSOPI ETAIRIA PERIORISMENIS EVTHINIS (Greece)

NATIONAL TECHNICAL UNIVERSITY OF ATHENS – NTUA (Greece)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN (Germany)

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON (Greece)

UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA (Romania)

TIME.LEX (Belgium)

 

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